Developmental excitatory-to-inhibitory GABA polarity switch is delayed in Ts65Dn mice, a genetic model of Down syndrome.

Lysenko, Larisa V; Kim, Jeesun; Madamba, Francisco; Tyrtyshnaia, Anna A; Ruparelia, Aarti; Kleschevnikov, Alexander M

Lysenko, Larisa V; Kim, Jeesun; Madamba, Francisco; Tyrtyshnaia, Anna A; Ruparelia, Aarti; Kleschevnikov, Alexander M.

Afiliación

Lysenko LV; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States; Academy of Biology and Biotechnology of Southern Federal University, 194/1 Stachki Ave, Rostov-na-Donu 344090, Russian Federation.
Kim J; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States.
Madamba F; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States.
Tyrtyshnaia AA; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok 690950, Russian Federation.
Ruparelia A; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States.
Kleschevnikov AM; Department of Neurosciences, University of California San Diego, 9500 Gilman Drive, La Jolla 92093, CA, United States; School of Biomedicine, Far Eastern Federal University, Sukhanova 8, Vladivostok 690950, Russian Federation. Electronic address: akleschevnikov@ucsd.edu.

Neurobiol Dis ; 115: 1-8, 2018 07.

Article en En | MEDLINE | ID: mdl-29550538

Asunto(s)

Potenciales de Acción/fisiología; Síndrome de Down/genética; Modelos Genéticos; Inhibición Neural/fisiología; Ácido gamma-Aminobutírico/fisiología; Potenciales de Acción/efectos de los fármacos; Animales; Células Cultivadas; Síndrome de Down/fisiopatología; Hipocampo/efectos de los fármacos; Hipocampo/fisiología; Masculino; Ratones; Ratones Endogámicos C3H; Ratones Endogámicos C57BL; Ratones Transgénicos; Técnicas de Cultivo de Órganos; Ácido gamma-Aminobutírico/farmacología

Palabras clave

Acute slices; Developmental excitatory-to-inhibitory GABA switch; Down syndrome; GDP; Giant depolarizing potentials; Hippocampus; MUA; Multi-unit activity; Neural circuits; Primary cultures

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Potenciales de Acción / Síndrome de Down / Ácido gamma-Aminobutírico / Modelos Genéticos / Inhibición Neural Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2018 Tipo del documento: Article

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