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Imaging intralesional heterogeneity of sodium concentration in multiple sclerosis: Initial evidence from 23Na-MRI.
Grist, James T; Riemer, Frank; McLean, Mary A; Matys, Tomasz; Zaccagna, Fulvio; Hilborne, Sarah F; Mason, Jackie P; Patterson, Ilse; Slough, Rhys; Kaggie, Joshua; Deen, Surrin S; Graves, Martin J; Jones, Joanne L; Coles, Alasdair J; Gallagher, Ferdia A.
Afiliación
  • Grist JT; Department of Radiology, University of Cambridge, Cambridge, UK. Electronic address: jtg26@cam.ac.uk.
  • Riemer F; Department of Radiology, University of Cambridge, Cambridge, UK.
  • McLean MA; Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK.
  • Matys T; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Zaccagna F; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Hilborne SF; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Mason JP; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Patterson I; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
  • Slough R; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
  • Kaggie J; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Deen SS; Department of Radiology, University of Cambridge, Cambridge, UK.
  • Graves MJ; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
  • Jones JL; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Coles AJ; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
  • Gallagher FA; Department of Radiology, University of Cambridge, Cambridge, UK; Department of Radiology, Addenbrooke's Hospital, Cambridge, UK.
J Neurol Sci ; 387: 111-114, 2018 04 15.
Article en En | MEDLINE | ID: mdl-29571845
Sodium MRI (23Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution 23Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using 23Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0.01), as well as a heterogeneous distribution of both the total tissue sodium concentration and the intracellular-weighted sodium concentration.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sodio / Encéfalo / Imagen por Resonancia Magnética / Esclerosis Múltiple Límite: Adult / Female / Humans Idioma: En Revista: J Neurol Sci Año: 2018 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sodio / Encéfalo / Imagen por Resonancia Magnética / Esclerosis Múltiple Límite: Adult / Female / Humans Idioma: En Revista: J Neurol Sci Año: 2018 Tipo del documento: Article