Notch signaling and neuronal death in stroke.
Prog Neurobiol
; 165-167: 103-116, 2018.
Article
en En
| MEDLINE
| ID: mdl-29574014
ABSTRACT
Ischemic stroke is a leading cause of morbidity and death, with the outcome largely determined by the amount of hypoxia-related neuronal death in the affected brain regions. Cerebral ischemia and hypoxia activate the Notch1 signaling pathway and four prominent interacting pathways (NF-κB, p53, HIF-1α and Pin1) that converge on a conserved DNA-associated nuclear multi-protein complex, which controls the expression of genes that can determine the fate of neurons. When neurons experience a moderate level of ischemic insult, the nuclear multi-protein complex up-regulates adaptive stress response genes encoding proteins that promote neuronal survival, but when ischemia is more severe the nuclear multi-protein complex induces genes encoding proteins that trigger and execute a neuronal death program. We propose that the nuclear multi-protein transcriptional complex is a molecular mediator of neuronal hormesis and a target for therapeutic intervention in stroke.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Transducción de Señal
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Hipoxia Encefálica
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Isquemia Encefálica
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Muerte Celular
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Accidente Cerebrovascular
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Receptores Notch
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Neuronas
Límite:
Animals
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Humans
Idioma:
En
Revista:
Prog Neurobiol
Año:
2018
Tipo del documento:
Article