Antibacterial secotirucallane triterpenes from the stem bark of Pseudocedrela kotschyi.
Z Naturforsch C J Biosci
; 73(5-6): 241-246, 2018 Apr 25.
Article
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| MEDLINE
| ID: mdl-29590084
ABSTRACT
The antibacterial-guided investigation of the stem bark extract of Pseudocedrela kotschyi led to the isolation of a new secotirucallane triterpene derivative 4-hydroxy-3,4-secotirucalla-7,24-dien-3,21-dioic acid (1), together with the known one 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (2) and 3-methyl ester 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic (3). The structures of the isolated compounds were elucidated on the basis of extensive 1D- and 2D-NMR spectroscopy. Extracts, fractions and compounds (1-3) were tested in vitro for antibacterial activity against two Gram positive bacteria (Bacillus subtilis and Staphylococcus aureus ATCC 25923), and two Gram negative bacteria (Escherichia coli S2(1) and Pseudomonas aeruginosa). The MeOH extract and the Hex/CH2Cl2 (7030) fraction showed significant levels of activity (MIC=64- 256 µg/mL) compared with the two reference drugs [ciprofloxacin MIC (0.5-1 µg/mL) and amoxicillin MIC (1-128 µg/mL)]. Moreover, the compound 2 isolated from this Hex/CH2Cl2 (7030) fraction had the greatest potential value against S. aureus, E. coli and P. aeruginosa, with minimum inhibitory concentrations (MIC) ranging from 4-16 µg/mL.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Triterpenos
/
Meliaceae
/
Antibacterianos
Idioma:
En
Revista:
Z Naturforsch C J Biosci
Año:
2018
Tipo del documento:
Article
País de afiliación:
Camerún