Highly sensitive label-free amperometric immunoassay of prostate specific antigen using hollow dendritic AuPtAg alloyed nanocrystals.
Biosens Bioelectron
; 111: 47-51, 2018 Jul 15.
Article
en En
| MEDLINE
| ID: mdl-29635117
ABSTRACT
Herein, well-defined hollow dendritic AuPtAg alloyed nanocrystals (ANCs) were synthesized by a simple L-proline-mediated one-pot aqueous method. More importantly, the synthesized hollow dendritic architectures provide a suitable platform for immobilization of anti-prostate specific antigen (PSA). The resultant label-free immunosensor exhibited the improved performance for highly sensitive detection of PSA based on the enhanced catalytic currents of K3[Fe(CN)6] as a signal probe. Impressively, the immunosensor showed the wide linear range of 0.05-50â¯ngâ¯mL-1 and low detection limit of 0.017â¯ngâ¯mL-1 under optimal conditions for the assay of PSA, couple with the improved stability, reproducibility and selectivity. It provides a promising platform for clinical research and diagnosis.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Platino (Metal)
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Plata
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Técnicas Biosensibles
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Antígeno Prostático Específico
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Aleaciones
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Nanopartículas
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Oro
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Humans
Idioma:
En
Revista:
Biosens Bioelectron
Asunto de la revista:
BIOTECNOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China