Efficacy of tocilizumab in Takayasu arteritis: Multicenter retrospective study of 46 patients.
J Autoimmun
; 91: 55-60, 2018 07.
Article
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| MEDLINE
| ID: mdl-29678346
ABSTRACT
OBJECTIVES:
To assess the efficacy of tocilizumab in patients with Takayasu arteritis (TA).METHODS:
We conducted a retrospective multicenter study in 46â¯TA patients treated with tocilizumab. We analyzed factors associated with response to tocilizumab (assessed using NIH score).RESULTS:
Forty-six patients with TA were included, with a median age of 43 years [29-54], and 35 (76%) females. We observed a decrease in the median NIH scale (from 3 [2-3] at baseline to 0 [0-1] and 0â¯at 3 and 6 months, respectively; pâ¯<â¯0.0001). The daily prednisone dose also decreased from 15â¯mg [8-19] at baseline to 4â¯mg [5-21] and 5â¯mg [4.5-9] at 3 and 6 months, respectively (pâ¯<â¯0.0001) under tocilizumab. The overall tocilizumab failure free survival was 81% [CI 95%; 0.7-0.95], 72% [CI 95%; 0.55-0.95] and 48% [CI 95%; 0.2-0.1] at 12, 24 and 48 months, respectively. The presence of constitutional symptoms (HR 5.6 [CI 95%; 1.08-29], pâ¯=â¯0.041), and C-reactive protein level (HR 1.16 [CI 95%; 1.01-1.31], Pâ¯=â¯0.003) at the time of tocilizumab initiation were significantly associated with tocilizumab event-free survival. The event-free survival was significantly better under tocilizumab therapy in comparison to DMARDs (pâ¯=â¯0.02).CONCLUSION:
This large multicenter study shows that tocilizumab is efficient and may reduce the incidence of relapses in TA.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Arteritis de Takayasu
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Antirreumáticos
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Anticuerpos Monoclonales Humanizados
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Inmunosupresores
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Autoimmun
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2018
Tipo del documento:
Article