[Research progress on the role of NLRP3 inflammasome in ocular diseases].
Zhonghua Yan Ke Za Zhi
; 54(5): 396-400, 2018 May 11.
Article
en Zh
| MEDLINE
| ID: mdl-29747372
ABSTRACT
Nucleotide-binding oligomerization domain-like receptor pyrin domain containing-3 (NLRP3) inflammasome is a type of multi-protein complex within the cell, the activation of which promotes the release of bioactive interleukin(IL)-1ß and IL-18 and contributes to inflammatory progress. In recent years, the research on the role of NLRP3 inflammasome in the pathogenesis and development of ocular surface and fundus diseases has made considerable progress. This review summarizes current understanding in the structure, ocular expression, and mechanisms of activation of NLRP3 inflammasome, as well as the contribution of this protein complex to eye diseases, thereby revealing the theoretical possibility that NLRP3 inflammasome might serve as a novel therapeutic target for the related ocular diseases.(Chin J Ophthalmol, 2018, 54 396-400).
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas Portadoras
/
Oftalmopatías
/
Inflamasomas
/
Proteína con Dominio Pirina 3 de la Familia NLR
Límite:
Humans
Idioma:
Zh
Revista:
Zhonghua Yan Ke Za Zhi
Año:
2018
Tipo del documento:
Article
País de afiliación:
China