Chemoenzymatic Synthesis of Advanced Intermediates for Formal Total Syntheses of Tetrodotoxin.
Angew Chem Int Ed Engl
; 57(34): 10994-10998, 2018 08 20.
Article
en En
| MEDLINE
| ID: mdl-29750851
ABSTRACT
Advanced intermediates for the syntheses of tetrodotoxin reported by the groups of Fukuyama, Alonso, and Sato were prepared. Key steps include the toluene dioxygenase mediated dihydroxylation of either iodobenzene or benzyl acetate. The resulting diene diols were transformed into Fukuyama's intermediate in six steps, into Alonso's intermediate in nine steps, and into Sato's intermediate in ten steps.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oxidorreductasas
/
Tetrodotoxina
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Año:
2018
Tipo del documento:
Article
País de afiliación:
Canadá