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Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice.
Zhang, Mei; Xie, Zhi-Fu; Zhang, Run-Tao; Chen, Da-Kai; Gu, Min; Cui, Shi-Chao; Zhang, Yang-Ming; Zhang, Xin-Wen; Yu, Yan-Yan; Li, Jia; Nan, Fa-Jun; Li, Jing-Ya.
Afiliación
  • Zhang M; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Xie ZF; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhang RT; University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Chen DK; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Gu M; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Cui SC; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhang YM; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Zhang XW; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Yu YY; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Li J; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Nan FJ; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
  • Li JY; State Key Laboratory of Drug Research, the National Drug Screening Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China. fjnan@simm.ac.cn.
Acta Pharmacol Sin ; 39(10): 1622-1632, 2018 Oct.
Article en En | MEDLINE | ID: mdl-29795358
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Activadores de Enzimas / Pirazolonas / Lipogénesis / Proteínas Quinasas Activadas por AMP / Enfermedad del Hígado Graso no Alcohólico Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Activadores de Enzimas / Pirazolonas / Lipogénesis / Proteínas Quinasas Activadas por AMP / Enfermedad del Hígado Graso no Alcohólico Límite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Asunto de la revista: FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China