Short-Term Hemodynamic Effects of Apelin in Patients With Pulmonary Arterial Hypertension.
JACC Basic Transl Sci
; 3(2): 176-186, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29876530
ABSTRACT
Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models. Here, the authors examined the short-term pulmonary hemodynamic effects of systemic apelin infusion in patients with PAH. In a double-blind randomized crossover study, 19 patients with PAH received intravenous (Pyr1)apelin-13 and matched saline placebo during invasive right heart catheterization. (Pyr1)apelin-13 infusion caused a reduction in pulmonary vascular resistance and increased cardiac output. This effect was accentuated in the subgroup of patients receiving concomitant phosphodiesterase type 5 inhibition. Apelin agonism is a novel potential therapeutic target for PAH. (Effects of Apelin on the Lung Circulation in Pulmonary Hypertension; NCT01457170).
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1
Bases de datos:
MEDLINE
Tipo de estudio:
Clinical_trials
Idioma:
En
Revista:
JACC Basic Transl Sci
Año:
2018
Tipo del documento:
Article
País de afiliación:
Reino Unido