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Apolipoprotein E plays crucial roles in maintaining bone mass by promoting osteoblast differentiation via ERK1/2 pathway and by suppressing osteoclast differentiation via c-Fos, NFATc1, and NF-κB pathway.
Noguchi, Takaaki; Ebina, Kosuke; Hirao, Makoto; Otsuru, Satoru; Guess, Adam J; Kawase, Ryota; Ohama, Tohru; Yamashita, Shizuya; Etani, Yuki; Okamura, Gensuke; Yoshikawa, Hideki.
Afiliación
  • Noguchi T; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Orthopaedic Surgery, Osaka Minami Medical Center, 2-1 Kidohigashimachi, Kawachinagano, Osaka, 586-8521, Japan.
  • Ebina K; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Electronic address: k-ebina@umin.ac.jp.
  • Hirao M; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Otsuru S; Department of Orthopaedics, University of Maryland School of Medicine, MD, 21201, USA.
  • Guess AJ; Center for Childhood Cancer and Blood Diseases, The Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
  • Kawase R; Department of Cardiovascular Medicine, Sousei Hospital, 596 Oaza-Yokochi, Kadoma, Osaka, 571-0023, Japan.
  • Ohama T; Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Dental Anesthesiology, Osaka University, Graduate School of Medicine, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Yamashita S; Department of Cardiovascular Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Community Medicine, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan; Rinku General Medical Center, 2-23 Ohrai-
  • Etani Y; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Okamura G; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Yoshikawa H; Department of Orthopaedic Surgery, Osaka University, Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
Biochem Biophys Res Commun ; 503(2): 644-650, 2018 09 05.
Article en En | MEDLINE | ID: mdl-29906458
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteoblastos / Osteoclastos / Osteoporosis / Apolipoproteínas E / Transducción de Señal Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteoblastos / Osteoclastos / Osteoporosis / Apolipoproteínas E / Transducción de Señal Límite: Animals Idioma: En Revista: Biochem Biophys Res Commun Año: 2018 Tipo del documento: Article País de afiliación: Japón