Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7.

Li, Xiaomin; Wang, Jianjun; Zhang, Chao; Lin, Chun; Zhang, Jianming; Zhang, Wei; Zhang, Wenjuan; Lu, Yanxia; Zheng, Lin; Li, Xuenong

Li, Xiaomin; Wang, Jianjun; Zhang, Chao; Lin, Chun; Zhang, Jianming; Zhang, Wei; Zhang, Wenjuan; Lu, Yanxia; Zheng, Lin; Li, Xuenong.

Afiliación

Li X; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Wang J; Department of Pathology, Department of Histology and Embryology, Wannan Medical College, Wuhu, PR China.
Zhang C; Department of Pathology, Department of Histology and Embryology, Wannan Medical College, Wuhu, PR China.
Lin C; Department of Pathology, Sun Yat-Sen University Cancer Centre, Guangzhou, PR China.
Zhang J; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang W; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Zhang W; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Lu Y; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Zheng L; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.
Li X; Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, PR China.

J Pathol ; 246(2): 166-179, 2018 10.

Article en En | MEDLINE | ID: mdl-29943828

Asunto(s)

Antígenos CD/metabolismo; Movimiento Celular; Proliferación Celular; Neoplasias Colorrectales/metabolismo; Cadenas alfa de Integrinas/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; ARN/metabolismo; Activación Transcripcional; Animales; Antígenos CD/genética; Células CACO-2; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/patología; Proteínas de Unión al ADN/genética; Proteínas de Unión al ADN/metabolismo; Femenino; Regulación Neoplásica de la Expresión Génica; Células HCT116; Humanos; Cadenas alfa de Integrinas/genética; Masculino; Ratones Endogámicos BALB C; Ratones Desnudos; MicroARNs/genética; MicroARNs/metabolismo; Persona de Mediana Edad; Metástasis de la Neoplasia; Neurofibromina 1/genética; Neurofibromina 1/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/genética; ARN/genética; ARN Circular; Transducción de Señal; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Carga Tumoral; Regulación hacia Arriba

Palabras clave

ITGA7; Ras pathway; circITGA7; circular RNAs; colorectal cancer; metastasis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ARN / Neoplasias Colorrectales / Antígenos CD / Activación Transcripcional / Movimiento Celular / Proteínas Proto-Oncogénicas p21(ras) / Cadenas alfa de Integrinas / Proliferación Celular Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Pathol Año: 2018 Tipo del documento: Article

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