The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.

Radwanska, Malwina J; Jaskólowski, Mateusz; Davydova, Elena; Derewenda, Urszula; Miyake, Tsuyoshi; Engel, Daniel A; Kossiakoff, Anthony A; Derewenda, Zygmunt S

Radwanska, Malwina J; Jaskólowski, Mateusz; Davydova, Elena; Derewenda, Urszula; Miyake, Tsuyoshi; Engel, Daniel A; Kossiakoff, Anthony A; Derewenda, Zygmunt S.

Afiliación

Radwanska MJ; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Jaskólowski M; Department of Biochemistry and Molecular Biology, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL 60637, USA.
Davydova E; Department of Biochemistry and Molecular Biology, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL 60637, USA.
Derewenda U; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Miyake T; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Engel DA; Department of Microbiology, Immunology and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
Kossiakoff AA; Department of Biochemistry and Molecular Biology, Knapp Center for Biomedical Discovery, University of Chicago, Chicago, IL 60637, USA.
Derewenda ZS; Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Acta Crystallogr D Struct Biol ; 74(Pt 7): 681-689, 2018 07 01.

Article en En | MEDLINE | ID: mdl-29968677

Asunto(s)

Complejo Antígeno-Anticuerpo/química; Ebolavirus/química; Fragmentos Fab de Inmunoglobulinas/química; Nucleoproteínas/química; Técnicas de Visualización de Superficie Celular; Cristalografía por Rayos X; Humanos; Fragmentos de Inmunoglobulinas/química; Biblioteca de Péptidos; Unión Proteica; Dominios Proteicos

Palabras clave

Ebola virus Bundibugyo strain; Ebola virus nucleoprotein; Fab structure; antibodyantigen interaction; synthetic antibody fragments

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / Ebolavirus / Complejo Antígeno-Anticuerpo / Nucleoproteínas Límite: Humans Idioma: En Revista: Acta Crystallogr D Struct Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos

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