A reliable LC-MS/MS method for the quantification of N-acetyl-p-benzoquinoneimine, acetaminophen glutathione and acetaminophen glucuronide in mouse plasma, liver and kidney: Method validation and application to a pharmacokinetic study.

Zhang, Xiqian; Li, Ruina; Hu, Wenya; Zeng, Jin; Jiang, Xuehua; Wang, Ling

Zhang, Xiqian; Li, Ruina; Hu, Wenya; Zeng, Jin; Jiang, Xuehua; Wang, Ling.

Afiliación

Zhang X; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
Li R; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
Hu W; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
Zeng J; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
Jiang X; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.
Wang L; Department of Clinical Pharmacy and Pharmacy Administration, Key Laboratory of Drug Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China.

Biomed Chromatogr ; 32(11): e4331, 2018 Nov.

Article en En | MEDLINE | ID: mdl-29978489

Asunto(s)

Acetaminofén/análogos & derivados; Benzoquinonas/análisis; Cromatografía Liquida/métodos; Iminas/análisis; Espectrometría de Masas en Tándem/métodos; Acetaminofén/análisis; Acetaminofén/farmacocinética; Animales; Benzoquinonas/farmacocinética; Iminas/farmacocinética; Límite de Detección; Modelos Lineales; Ratones; Ratones Endogámicos ICR; Reproducibilidad de los Resultados; Distribución Tisular

Palabras clave

LC-MS/MS; NAPQI; acetaminophen-gluc; acetaminophen-glut; pharmacokinetics

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Benzoquinonas / Cromatografía Liquida / Espectrometría de Masas en Tándem / Iminas / Acetaminofén Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Biomed Chromatogr Año: 2018 Tipo del documento: Article País de afiliación: China

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