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Smart Bandage for Monitoring and Treatment of Chronic Wounds.
Mostafalu, Pooria; Tamayol, Ali; Rahimi, Rahim; Ochoa, Manuel; Khalilpour, Akbar; Kiaee, Gita; Yazdi, Iman K; Bagherifard, Sara; Dokmeci, Mehmet R; Ziaie, Babak; Sonkusale, Sameer R; Khademhosseini, Ali.
Afiliación
  • Mostafalu P; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Tamayol A; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Rahimi R; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
  • Ochoa M; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Khalilpour A; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Kiaee G; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, 02115, USA.
  • Yazdi IK; Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, Lincoln, NE, 68588, USA.
  • Bagherifard S; Birck Nanotechnology Center, School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.
  • Dokmeci MR; Birck Nanotechnology Center, School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN, 47907, USA.
  • Ziaie B; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
  • Sonkusale SR; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
  • Khademhosseini A; Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.
Small ; : e1703509, 2018 Jul 06.
Article en En | MEDLINE | ID: mdl-29978547
ABSTRACT
Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide. The wound environment is dynamic, but their healing rate can be enhanced by administration of therapies at the right time. This approach requires real-time monitoring of the wound environment with on-demand drug delivery in a closed-loop manner. In this paper, a smart and automated flexible wound dressing with temperature and pH sensors integrated onto flexible bandages that monitor wound status in real-time to address this unmet medical need is presented. Moreover, a stimuli-responsive drug releasing system comprising of a hydrogel loaded with thermo-responsive drug carriers and an electronically controlled flexible heater is also integrated into the wound dressing to release the drugs on-demand. The dressing is equipped with a microcontroller to process the data measured by the sensors and to program the drug release protocol for individualized treatment. This flexible smart wound dressing has the potential to significantly impact the treatment of chronic wounds.
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Revista: Small Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos