Your browser doesn't support javascript.
loading
Ca2+tapulting HSCs into action.
Guitart, Amelie V; Finch, Andrew J; Kranc, Kamil R.
Afiliación
  • Guitart AV; MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
  • Finch AJ; INSERM U1035, Université Bordeaux, Bordeaux, France.
  • Kranc KR; Cancer Research UK Edinburgh Centre, University of Edinburgh, UK.
J Exp Med ; 215(8): 1971-1973, 2018 08 06.
Article en En | MEDLINE | ID: mdl-30002075
ABSTRACT
In this issue of JEM, Umemoto et al. (https//doi.org/10.1084/jem.20180421) demonstrate that calcium influx stimulates mitochondrial metabolism and initiates proliferation in hematopoietic stem cells (HSCs). Extracellular adenosine, sourced from surrounding hematopoietic progenitors, inhibits this calcium influx, thereby suppressing mitochondrial metabolism and promoting HSC quiescence. This is the first demonstration that a calcium-mitochondria pathway regulates HSC division.
Asunto(s)
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Calcio Idioma: En Revista: J Exp Med Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Células Madre Hematopoyéticas / Calcio Idioma: En Revista: J Exp Med Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido