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PI3Kδ hyper-activation promotes development of B cells that exacerbate Streptococcus pneumoniae infection in an antibody-independent manner.
Stark, Anne-Katrien; Chandra, Anita; Chakraborty, Krishnendu; Alam, Rafeah; Carbonaro, Valentina; Clark, Jonathan; Sriskantharajah, Srividya; Bradley, Glyn; Richter, Alex G; Banham-Hall, Edward; Clatworthy, Menna R; Nejentsev, Sergey; Hamblin, J Nicole; Hessel, Edith M; Condliffe, Alison M; Okkenhaug, Klaus.
Afiliación
  • Stark AK; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Chandra A; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
  • Chakraborty K; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Alam R; Division of Immunology, Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK.
  • Carbonaro V; Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ, UK.
  • Clark J; Cambridge University Hospitals NHS Trust, Hills Road, Cambridge, CB2 0QQ, UK.
  • Sriskantharajah S; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Bradley G; Department of Medicine, University of Cambridge, Cambridge, CB2 OQQ, UK.
  • Richter AG; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Banham-Hall E; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Clatworthy MR; Biological Chemistry Laboratory, Babraham Institute, Cambridge, CB21 3AT, UK.
  • Nejentsev S; Refractory Respiratory Inflammation Discovery Performance Unit, Respiratory Therapy Area, GlaxoSmithKline, Stevenage, SG1 2NY, UK.
  • Hamblin JN; Computational Biology and Statistics, Target Sciences, GlaxoSmithKline, Stevenage, SG1 2NY, UK.
  • Hessel EM; Department of Immunology, Queen Elizabeth Hospital, Birmingham, B15 2TH, UK.
  • Condliffe AM; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, UK.
  • Okkenhaug K; Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, CB21 3AT, UK.
Nat Commun ; 9(1): 3174, 2018 08 09.
Article en En | MEDLINE | ID: mdl-30093657
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Linfocitos B / Fosfatidilinositol 3-Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Linfocitos B / Fosfatidilinositol 3-Quinasas / Inhibidores de las Quinasa Fosfoinosítidos-3 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Reino Unido