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Fibrolamellar Hepatocellular Carcinoma with Multiple Lung Metastases Treated with Multidisciplinary Therapy.
Tanaka, Hiroki; Hijioka, Susumu; Iwaya, Hiromichi; Mizuno, Nobumasa; Kuwahara, Takamichi; Okuno, Nozomi; Ito, Ayako; Kuraoka, Naosuke; Matsumoto, Shinpei; Obata, Masahiro; Kurita, Yusuke; Yasuda, Muneji; Shimizu, Yasuhiro; Kuroda, Hiroaki; Sato, Yozo; Haneda, Masataka; Sasaki, Eiichi; Yatabe, Yasushi; Hara, Kazuo.
Afiliación
  • Tanaka H; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Hijioka S; Department of Gastroenterology, Suzuka General Hospital, Japan.
  • Iwaya H; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Mizuno N; Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, Japan.
  • Kuwahara T; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Okuno N; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Ito A; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Kuraoka N; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Matsumoto S; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Obata M; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Kurita Y; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Yasuda M; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Shimizu Y; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Kuroda H; Department of Gastroenterology, Aichi Cancer Center Hospital, Japan.
  • Sato Y; Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Japan.
  • Haneda M; Department of Thoracic Surgery, Aichi Cancer Center Hospital, Japan.
  • Sasaki E; Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Japan.
  • Yatabe Y; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Japan.
  • Hara K; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Japan.
Intern Med ; 57(24): 3537-3543, 2018 Dec 15.
Article en En | MEDLINE | ID: mdl-30101933
A 20-year old man was diagnosed with fibrolamellar hepatocellular carcinoma (FLHCC) with multiple lung metastases, and chemotherapy with FOLFOX was administered. Contrast enhanced CT after 3 cycles of FOLFOX showed no disease progression. We therefore performed surgical resection and radiofrequency ablation of the liver lesions and lung metastases, after obtaining the patient's informed consent. The liver lesions and lung metastases tested positive for DNAJB1-PRKACA. The treatment for FLHCC with extrahepatic metastasis has not been established; however, in a few cases, good long-term prognoses were obtained with multidisciplinary therapy. We herein report a case of FLHCC with multiple lung metastases that was treated with multidisciplinary therapies.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2018 Tipo del documento: Article País de afiliación: Japón
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas / Neoplasias Pulmonares Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Humans / Male Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2018 Tipo del documento: Article País de afiliación: Japón