Alveolar Air and O2 Uptake During Exercise in Patients With Heart Failure.
J Card Fail
; 24(10): 695-705, 2018 Oct.
Article
en En
| MEDLINE
| ID: mdl-30103021
ABSTRACT
BACKGROUND:
Peak exercise pulmonary oxygen uptake (VÌO2) is a primary marker of prognosis in heart failure (HF). The pathophysiology of impaired peak VÌO2 is unclear in patients. To what extent alveolar airway function affects VÌO2 during cardiopulmonary exercise testing (CPET) has not been fully elucidated. This study aimed to describe how changes in alveolar ventilation (VÌA), volume (VA), and related parameters couple with exercise VÌO2 in HF. METHODS ANDRESULTS:
A total of 35 patients with HF (left ventricular ejection fraction 20 ± 6%, age 53 ± 7 y) participated in CPET with breath-to-breath measurements of ventilation and gas exchange. At rest, 20 W, and peak exercise, arterial CO2 tension was measured via radial arterial catheterization and used in alveolar equations to derive VÌA and VA. Resting lung diffusion capacity for carbon monoxide (DLCO) was assessed and indexed to VA for each time point. Resting R2 between VÌO2 and VÌA, VA, DLCO, and DLCO/VA was 0.68, 0.18, 0.20, and 0.07, respectively (all P < .05 except DLCO/VA). 20 W R2 between VÌO2 and VÌA, VA, DLCO, and DLCO/VA was 0.64, 0.32, 0.07, and 0.18 (all P < .05 except DLCO). Peak exercise R2 between VÌO2 and VÌA, VA, DLCO, and DLCO/VA was 0.55, 0.31, 0.34, and 0.06 (all P < .05 except DLCO/VA).CONCLUSIONS:
These data suggest that alveolar airway function that is not exclusively related to effects caused by localized lung diffusivity affects exercise VÌO2 in moderate-to-severe HF.Palabras clave
Texto completo:
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Bases de datos:
MEDLINE
Asunto principal:
Consumo de Oxígeno
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Alveolos Pulmonares
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Capacidad de Difusión Pulmonar
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Tolerancia al Ejercicio
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Insuficiencia Cardíaca
Límite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Card Fail
Asunto de la revista:
CARDIOLOGIA
Año:
2018
Tipo del documento:
Article