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Comparable efficacy of adapalene 0.3% gel and tretinoin 0.05% cream as treatment for cutaneous photoaging.
Bagatin, Ediléia; Gonçalves, Heitor de Sá; Sato, Maurício; Almeida, Luiz Maurício Costa; Miot, Helio Amante.
Afiliación
  • Bagatin E; Professor, Department of Dermatology, Federal University of São Paulo, SP, Brazil. Thesis advisor, Translational Medicine Post-Graduation Program, Federal University of São Paulo, São Paulo, Brazil.
  • Gonçalves HS; Director, Dona Libânia Dermatology center, Department of Health, Ceará, Brazil.
  • Sato M; Dermatologist, Federal University of Paraná, Paraná, Brazil.
  • Almeida LMC; Professor; Department of Dermatology, Medical Sciences College, Minas Gerais, Brazil. Preceptor of the medical residency of the Santa Casa, Minas Gerais, Brazil.
  • Miot HA; Associate professor, Department of Dermatology, FMB-Unesp, São Paulo Brazil.
Eur J Dermatol ; 28(3): 343-350, 2018 Jun 01.
Article en En | MEDLINE | ID: mdl-30105991
BACKGROUND: Adapalene has been previously evaluated as a treatment for actinic keratosis (AK) and solar lentigines and shown to improve signs of photoaging. OBJECTIVES: To evaluate whether adapalene 0.3% gel is non-inferior to tretinoin 0.05% cream as treatment for photoaged skin. MATERIALS & METHODS: An investigator-blinded, parallel-group comparison study was conducted in Brazil. Subjects were randomised in a 1:1 ratio to receive, once daily, adapalene 0.3% gel or tretinoin 0.05% cream. Subjects were evaluated at Weeks 1, 4, 8, 12, 16, 20 and 24, based on clinical signs of cutaneous photoaging, histopathological and digital morphometric findings, as well as safety and tolerability. RESULTS: A comparison of clinical efficacy showed that both treatments did not differ significantly regarding clinical evaluation of the following criteria: global cutaneous photoaging, periorbital wrinkles, ephelides/melanosis, forehead wrinkles, and AK. CONCLUSION: Adapalene 0.3% gel showed non-inferior efficacy to tretinoin 0.05% cream as treatment for photoaged skin, with a similar safety profile. Adapalene 0.3% gel may therefore be considered a safe and effective option for the treatment of mild or moderate photoaging.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tretinoina / Envejecimiento de la Piel / Fármacos Dermatológicos / Adapaleno Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Dermatol Asunto de la revista: DERMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Tretinoina / Envejecimiento de la Piel / Fármacos Dermatológicos / Adapaleno Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur J Dermatol Asunto de la revista: DERMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Brasil