Targeting Breast Cancer Stem Cells: A Methodological Perspective.
Curr Stem Cell Res Ther
; 14(5): 389-397, 2019.
Article
en En
| MEDLINE
| ID: mdl-30147014
ABSTRACT
Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Madre Neoplásicas
/
Neoplasias de la Mama
/
Antineoplásicos
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Curr Stem Cell Res Ther
Asunto de la revista:
TERAPEUTICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
México