Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature.
Diagn Pathol
; 13(1): 62, 2018 Aug 28.
Article
en En
| MEDLINE
| ID: mdl-30153845
ABSTRACT
BACKGROUND:
Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic lobular carcinoma (PLC) is a distinct morphological variant of invasive lobular carcinoma characterized by higher nuclear atypia and pleomorphism than the classical type. In the best of our knowledge, a PLC with OGCs has not been previously reported. CASE PRESENTATION We report the case of a 72-year-old woman presenting with a pleomorphic tumor of the left breast with a dense infiltration by OGCs and T lymphocytes with a 101 predominance of CD8+ over CD4+ cells. The diagnosis of a lymphoid or mesenchymal neoplasia was excluded after demonstrating keratin expression by the neoplastic cells. The absence of E-cadherin expression and the morphological features were consistent with the diagnosis PLC with OGCs. In addition, we demonstrated the deleterious mutation C.del866C in CDH1gene, but no mutations in any of the other 33 genes analyzed by next generation sequencing.CONCLUSIONS:
Breast carcinoma with stromal osteoclast-like giant cells is a very rare tumor, for that reason, the use of the cytologic features and growth patterns in combination with immunohistochemically studies is mandatory for a correct diagnosis of lobular carcinoma. In addition, further studies are necessary to clarify the influence of OGCs in the prognosis of these patients.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Osteoclastos
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Neoplasias de la Mama
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Células Gigantes
/
Carcinoma Lobular
Tipo de estudio:
Prognostic_studies
Límite:
Aged
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Female
/
Humans
Idioma:
En
Revista:
Diagn Pathol
Asunto de la revista:
PATOLOGIA
Año:
2018
Tipo del documento:
Article
País de afiliación:
España