Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and <i>ADAMTS-5</i> mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs.

Luo, Dan; Shen, Yan; Lyu, Jian-Qiang; Fan, Yong-Qian; Huang, Dong-Hui; Lin, Wei-Long; Shen, Hai-Min; Xu, Hu-Ji; Guan, Jian-Long

Effect of Mechanical Stress in Combination with Verapamil on Levels of Aggrecan and ADAMTS-5 mRNAs and Proteins in Human Osteoarthritic Chondrocyte/Agarose Constructs.

Luo, Dan; Shen, Yan; Lyu, Jian-Qiang; Fan, Yong-Qian; Huang, Dong-Hui; Lin, Wei-Long; Shen, Hai-Min; Xu, Hu-Ji; Guan, Jian-Long.

Afiliación

Luo D; Department of Rheumatology, Huadong Hospital, Fudan University, Shanghai 200040, China.
Shen Y; Department of Rheumatology, Huadong Hospital, Fudan University, Shanghai 200040, China.
Lyu JQ; Key Laboratory of Exercise and Health Sciences of Ministry of Education, School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Fan YQ; Department of Orthopedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China.
Huang DH; Department of Orthopedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China.
Lin WL; Department of Orthopedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China.
Shen HM; Department of Orthopedic Surgery, Huadong Hospital, Fudan University, Shanghai 200040, China.
Xu HJ; Department of Rheumatology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Guan JL; Department of Rheumatology, Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai 200040, China.

Chin Med J (Engl) ; 131(18): 2229-2231, 2018 09 20.

Article en En | MEDLINE | ID: mdl-30203799

Asunto(s)

Proteína ADAMTS5/metabolismo; Agrecanos/metabolismo; Matriz Extracelular/efectos de los fármacos; Matriz Extracelular/metabolismo; Osteoartritis/metabolismo; ARN Mensajero/metabolismo; Estrés Mecánico; Verapamilo/farmacología; Proteína ADAMTS4/genética; Proteína ADAMTS4/metabolismo; Proteína ADAMTS5/genética; Anciano; Agrecanos/genética; Células Cultivadas; Condrocitos/efectos de los fármacos; Condrocitos/metabolismo; Colágeno Tipo II/metabolismo; Humanos; Persona de Mediana Edad; ARN Mensajero/genética

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteoartritis / Estrés Mecánico / ARN Mensajero / Verapamilo / Matriz Extracelular / Agrecanos / Proteína ADAMTS5 Límite: Aged / Humans / Middle aged Idioma: En Revista: Chin Med J (Engl) Año: 2018 Tipo del documento: Article País de afiliación: China

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