Methylation status of ORMDL3 regulates cytokine production and p-ERK/MMP9 pathway expression.

Wu, Xiao-Lu; Li, Ran; Zhang, Hui-Wen; Jin, Rui; Wang, Jin-Ya; Juan, Chen-Xia; Lu, Kang; Shu, Jin; Wang, Lu-Lu; Wang, Yi; Zhuang, Li-Li; Zhou, Guo-Ping

Wu, Xiao-Lu; Li, Ran; Zhang, Hui-Wen; Jin, Rui; Wang, Jin-Ya; Juan, Chen-Xia; Lu, Kang; Shu, Jin; Wang, Lu-Lu; Wang, Yi; Zhuang, Li-Li; Zhou, Guo-Ping.

Afiliación

Wu XL; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Li R; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhang HW; Department of Surgical Intensive Care Unit, Nanjing Children's Hospital, 210000, China.
Jin R; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wang JY; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Juan CX; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Lu K; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Shu J; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wang LL; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Wang Y; Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Zhuang LL; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: olourphy@126.com.
Zhou GP; Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: zhouguopingek@163.com.

Exp Cell Res ; 372(1): 43-51, 2018 11 01.

Article en En | MEDLINE | ID: mdl-30217493

Asunto(s)

Asma/genética; Epigénesis Genética; Metaloproteinasa 9 de la Matriz/genética; Proteínas de la Membrana/genética; Proteína Quinasa 1 Activada por Mitógenos/genética; Proteína Quinasa 3 Activada por Mitógenos/genética; Adolescente; Asma/metabolismo; Asma/patología; Secuencia de Bases; Estudios de Casos y Controles; Línea Celular Transformada; Niño; Islas de CpG; Decitabina/farmacología; Células Epiteliales/efectos de los fármacos; Células Epiteliales/metabolismo; Células Epiteliales/patología; Femenino; Humanos; Interleucina-6/genética; Interleucina-6/metabolismo; Interleucina-8/genética; Interleucina-8/metabolismo; Masculino; Metaloproteinasa 9 de la Matriz/metabolismo; Proteínas de la Membrana/metabolismo; Metilación; Proteína Quinasa 1 Activada por Mitógenos/metabolismo; Proteína Quinasa 3 Activada por Mitógenos/metabolismo; Regiones Promotoras Genéticas; Mucosa Respiratoria/metabolismo; Mucosa Respiratoria/patología; Transducción de Señal

Palabras clave

5-Aza-CdR-2'-deoxycytidine; Childhood asthma; DNA methylation; IL-6, IL-8; MMP-9; ORMDL3; p-ERK

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Asma / Proteína Quinasa 1 Activada por Mitógenos / Metaloproteinasa 9 de la Matriz / Epigénesis Genética / Proteína Quinasa 3 Activada por Mitógenos / Proteínas de la Membrana Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Exp Cell Res Año: 2018 Tipo del documento: Article País de afiliación: China

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