Unusual cadinane-type sesquiterpene glycosides with α-glucosidase inhibitory activities from the fruit of Cornus officinalis Sieb. et Zuuc.
Bioorg Chem
; 82: 1-5, 2019 02.
Article
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| MEDLINE
| ID: mdl-30267969
ABSTRACT
Five novel and rare cadinane-type sesquiterpene glycosides, cornucadinoside A-E (1-5) were isolated from water extract of the fruit of Cornus officinalis Sieb. et Zuuc.. The new chemical structures, together with their absolute configurations, were elucidated on the basis of extensive spectroscopic analysis, including a comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. Their structures, which possess a naphthalene skeleton, are the first report on the occurrence of cadinane sesquiterpene glycosides in Cornus. Additionally, all the compounds exhibited marked α-glucosidase inhibitory activity except for 3in vitro.
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1
Bases de datos:
MEDLINE
Asunto principal:
Sesquiterpenos
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Cornus
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Inhibidores de Glicósido Hidrolasas
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Frutas
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Glicósidos
Idioma:
En
Revista:
Bioorg Chem
Año:
2019
Tipo del documento:
Article