Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission.

Yao, Xudong; Zhang, Jiaming; Jing, Xingzhi; Ye, Yaping; Guo, Jiachao; Sun, Kai; Guo, Fengjing

Yao, Xudong; Zhang, Jiaming; Jing, Xingzhi; Ye, Yaping; Guo, Jiachao; Sun, Kai; Guo, Fengjing.

Afiliación

Yao X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: 602983321@qq.com.
Zhang J; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: 584297095@qq.com.
Jing X; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: jingxingzhi@outlook.com.
Ye Y; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: yypatpenn@gmail.com.
Guo J; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: 793527829@qq.com.
Sun K; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: 1085844308@qq.com.
Guo F; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. Electronic address: guofjdoc@163.com.

Pharmacol Res ; 139: 314-324, 2019 01.

Article en En | MEDLINE | ID: mdl-30273654

Asunto(s)

Factores de Crecimiento de Fibroblastos/farmacología; Factores de Crecimiento de Fibroblastos/uso terapéutico; Dinámicas Mitocondriales/efectos de los fármacos; Osteoartritis/tratamiento farmacológico; Osteoartritis/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas Recombinantes/uso terapéutico; Animales; Células Cultivadas; Condrocitos/efectos de los fármacos; Condrocitos/fisiología; Masculino; Ratas Sprague-Dawley; Proteínas Recombinantes/farmacología; Transducción de Señal/efectos de los fármacos

Palabras clave

AZD5363 (PubChem CID: 25227436); Apoptosis; Fibroblast growth factor 18; GDC-0032 (PubChem CID: 51001932); IL-1ß (PubChem CID: 123872); Mitochondrial; Osteoarthritis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteoartritis / Proteínas Recombinantes / Fosfatidilinositol 3-Quinasas / Proteínas Proto-Oncogénicas c-akt / Factores de Crecimiento de Fibroblastos / Dinámicas Mitocondriales Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2019 Tipo del documento: Article

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