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The class I myosin MYO1D binds to lipid and protects against colitis.
McAlpine, William; Wang, Kuan-Wen; Choi, Jin Huk; San Miguel, Miguel; McAlpine, Sarah Grace; Russell, Jamie; Ludwig, Sara; Li, Xiaohong; Tang, Miao; Zhan, Xiaoming; Choi, Mihwa; Wang, Tao; Bu, Chun Hui; Murray, Anne R; Moresco, Eva Marie Y; Turer, Emre E; Beutler, Bruce.
Afiliación
  • McAlpine W; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Wang KW; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Choi JH; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • San Miguel M; Department of Internal Medicine, Division of Gastroenterology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505 USA.
  • McAlpine SG; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Russell J; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Ludwig S; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Li X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Tang M; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Zhan X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Choi M; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Wang T; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Bu CH; Quantitative Biomedical Research Center, Department of Clinical Science, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
  • Murray AR; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Moresco EMY; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Turer EE; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
  • Beutler B; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA.
Dis Model Mech ; 11(9)2018 09 27.
Article en En | MEDLINE | ID: mdl-30279225
ABSTRACT
Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Miosinas / Colitis / Lípidos de la Membrana Límite: Animals Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Miosinas / Colitis / Lípidos de la Membrana Límite: Animals Idioma: En Revista: Dis Model Mech Asunto de la revista: MEDICINA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos