Synthesis of medium-sized (6-7-6) ring compounds by iron-catalyzed C-H activation/annulation [corrected].
Org Biomol Chem
; 16(42): 7861-7870, 2018 10 31.
Article
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| MEDLINE
| ID: mdl-30303228
ABSTRACT
In this report, we have described a FeCl3-catalyzed process involving intramolecular annulation of o-phenoxy diarylacetylenes via hydroarylation to afford a series of biologically potent fused seven-membered (6-7-6) ring compounds under mild reaction conditions. This reaction was believed to proceed through Friedel-Crafts type sequential carbometallation followed by protonation to produce phenyldibenz[b,f]oxepines. This method was also extended to synthesize seven-membered rings that are fused with coumarins.
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MEDLINE
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En
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Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
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QUIMICA
Año:
2018
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Article