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Improved Therapeutic Window in BRCA-mutant Tumors with Antibody-linked Pyrrolobenzodiazepine Dimers with and without PARP Inhibition.
Zhong, Haihong; Chen, Cui; Tammali, Ravinder; Breen, Shannon; Zhang, Jing; Fazenbaker, Christine; Kennedy, Maureen; Conway, James; Higgs, Brandon W; Holoweckyj, Nicholas; Raja, Rajiv; Harper, Jay; Pierce, Andrew J; Herbst, Ronald; Tice, David A.
Afiliación
  • Zhong H; Oncology Research, MedImmune, Gaithersburg, Maryland. zhongh@medimmune.com ticed@medimmune.com.
  • Chen C; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Tammali R; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Breen S; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Zhang J; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Fazenbaker C; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Kennedy M; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Conway J; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Higgs BW; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Holoweckyj N; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Raja R; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Harper J; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Pierce AJ; Translational Science - Oncology, Innovative Medicines and Early Development, AstraZeneca, Cambridge, United Kingdom.
  • Herbst R; Oncology Research, MedImmune, Gaithersburg, Maryland.
  • Tice DA; Oncology Research, MedImmune, Gaithersburg, Maryland. zhongh@medimmune.com ticed@medimmune.com.
Mol Cancer Ther ; 18(1): 89-99, 2019 01.
Article en En | MEDLINE | ID: mdl-30352801
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ftalazinas / Piperazinas / Pirroles / Benzodiazepinas / Inmunoconjugados / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Antineoplásicos Inmunológicos / Neoplasias Experimentales Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2019 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ftalazinas / Piperazinas / Pirroles / Benzodiazepinas / Inmunoconjugados / Inhibidores de Poli(ADP-Ribosa) Polimerasas / Antineoplásicos Inmunológicos / Neoplasias Experimentales Límite: Animals / Humans Idioma: En Revista: Mol Cancer Ther Asunto de la revista: ANTINEOPLASICOS Año: 2019 Tipo del documento: Article