Editome Disease Knowledgebase (EDK): a curated knowledgebase of editome-disease associations in human.
Nucleic Acids Res
; 47(D1): D78-D83, 2019 01 08.
Article
en En
| MEDLINE
| ID: mdl-30357418
ABSTRACT
RNA editing, as an essential co-/post-transcriptional RNA modification type, plays critical roles in many biological processes and involves with a variety of human diseases. Although several databases have been developed to collect RNA editing data in both model and non-model animals, there still lacks a resource integrating associations between editome and human disease. In this study, we present Editome-Disease Knowledgebase (EDK; http//bigd.big.ac.cn/edk), an integrated knowledgebase of RNA editome-disease associations manually curated from published literatures. In the current version, EDK incorporates 61 diseases associated with 248 experimentally validated abnormal editing events located in 32 mRNAs, 16 miRNAs, 1 lncRNA and 11 viruses, and 44 aberrant activities involved with 6 editing enzymes, which together are curated from more than 200 publications. In addition, to facilitate standardization of editome-disease knowledge integration, we propose a data curation model in EDK, factoring an abundance of relevant information to fully capture the context of editome-disease associations. Taken together, EDK is a comprehensive collection of editome-disease associations and bears the great utility in aid of better understanding the RNA editing machinery and complex molecular mechanisms associated with human diseases.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Procesamiento Postranscripcional del ARN
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Edición de ARN
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Biología Computacional
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Predisposición Genética a la Enfermedad
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Bases de Datos Genéticas
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Estudio de Asociación del Genoma Completo
Tipo de estudio:
Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Nucleic Acids Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
China