Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during <i>Yersinia</i> infection.

Sarhan, Joseph; Liu, Beiyun C; Muendlein, Hayley I; Li, Peng; Nilson, Rachael; Tang, Amy Y; Rongvaux, Anthony; Bunnell, Stephen C; Shao, Feng; Green, Douglas R; Poltorak, Alexander

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.

Sarhan, Joseph; Liu, Beiyun C; Muendlein, Hayley I; Li, Peng; Nilson, Rachael; Tang, Amy Y; Rongvaux, Anthony; Bunnell, Stephen C; Shao, Feng; Green, Douglas R; Poltorak, Alexander.

Afiliación

Sarhan J; Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, Boston, MA 02111.
Liu BC; Medical Scientist Training Program, Tufts University School of Medicine, Boston, MA 02111.
Muendlein HI; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111.
Li P; Graduate Program in Immunology, Tufts University Sackler School of Biomedical Sciences, Boston, MA 02111.
Nilson R; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111.
Tang AY; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111.
Rongvaux A; Graduate Program in Genetics, Tufts University Sackler School of Biomedical Sciences, Boston, MA 02111.
Bunnell SC; Collaborative Innovation Center for Cancer Medicine, National Institute of Biological Sciences, 102206 Beijing, China.
Shao F; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111.
Green DR; Department of Immunology, Tufts University School of Medicine, Boston, MA 02111.
Poltorak A; Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109.

Proc Natl Acad Sci U S A ; 115(46): E10888-E10897, 2018 11 13.

Article en En | MEDLINE | ID: mdl-30381458

Asunto(s)

Proteínas Reguladoras de la Apoptosis/metabolismo; Caspasa 8/metabolismo; Yersiniosis/metabolismo; Animales; Apoptosis/fisiología; Proteínas Bacterianas/metabolismo; Humanos; Interleucina-1/metabolismo; Péptidos y Proteínas de Señalización Intracelular; Lipopolisacáridos/farmacología; Quinasas Quinasa Quinasa PAM/antagonistas & inhibidores; Quinasas Quinasa Quinasa PAM/metabolismo; Macrófagos/metabolismo; Ratones; Ratones Endogámicos C57BL; Proteínas de Unión a Fosfato; Piroptosis/fisiología; Yersiniosis/patología; Yersinia pseudotuberculosis/metabolismo

Palabras clave

TAK1; Yersinia; caspase-8; gasdermin; pyroptosis

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Yersiniosis / Proteínas Reguladoras de la Apoptosis / Caspasa 8 Límite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2018 Tipo del documento: Article

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