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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders.
Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G; de Vries, Paul S; Prins, Bram P; Van der Most, Peter J; Tanaka, Toshiko; Naderi, Elnaz; Rose, Lynda M; Wu, Ying; Karlsson, Robert; Barbalic, Maja; Lin, Honghuang; Pool, René; Zhu, Gu; Macé, Aurélien; Sidore, Carlo; Trompet, Stella; Mangino, Massimo; Sabater-Lleal, Maria; Kemp, John P; Abbasi, Ali; Kacprowski, Tim; Verweij, Niek; Smith, Albert V; Huang, Tao; Marzi, Carola; Feitosa, Mary F; Lohman, Kurt K; Kleber, Marcus E; Milaneschi, Yuri; Mueller, Christian; Huq, Mahmudul; Vlachopoulou, Efthymia; Lyytikäinen, Leo-Pekka; Oldmeadow, Christopher; Deelen, Joris; Perola, Markus; Zhao, Jing Hua; Feenstra, Bjarke; Amini, Marzyeh; Lahti, Jari; Schraut, Katharina E; Fornage, Myriam; Suktitipat, Bhoom; Chen, Wei-Min; Li, Xiaohui; Nutile, Teresa; Malerba, Giovanni.
Afiliación
  • Ligthart S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands.
  • Vaez A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran.
  • Võsa U; Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu 51010, Estonia.
  • Stathopoulou MG; Université de Lorraine, INSERM, IGE-PCV, 54000 Nancy, France.
  • de Vries PS; Department of Epidemiology, Erasmus University Medical Center, Rotterdam 3000 CA, the Netherlands; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Prins BP; Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK.
  • Van der Most PJ; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
  • Tanaka T; Translational Gerontology Branch, National Institute on Aging, Baltimore, MD 21224, USA.
  • Naderi E; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands.
  • Rose LM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
  • Wu Y; Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
  • Karlsson R; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
  • Barbalic M; University of Split School of Medicine, Split 21000, Croatia.
  • Lin H; Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  • Pool R; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam 1081 BT, the Netherlands; Amsterdam Public Health research institute, VU University Medical Center, Amsterdam 1081 BT, the Netherlands.
  • Zhu G; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
  • Macé A; Department of Computational Biology, University of Lausanne, Lausanne 1010, Switzerland; Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland; Institute of Social and Preventive Medicine, University Hospital of Lausanne, Lausanne 1010, Switzerland.
  • Sidore C; Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Sardinia 08045, Italy.
  • Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden 2300 RC, the Netherlands; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2333 ZA, the Netherlands.
  • Mangino M; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK; NIHR Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London SE1 9RT, UK.
  • Sabater-Lleal M; Unit of Genomics of Complex Diseases, Institut d'Investigació Biomèdica Sant Pau, Barcelona 08025, Spain; Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet, Stockholm 17176, Sweden.
  • Kemp JP; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK.
  • Abbasi A; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands; Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the Netherlands; MRC Epidemiology Unit, University of Cambri
  • Kacprowski T; Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt University Greifswald, Greifswald 17475, Germany; German Centre for Cardiovascular Research, Partner Site Greifswald, Greifswald 17475, Germany.
  • Verweij N; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen 9713 AV, the Netherlands.
  • Smith AV; Icelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
  • Huang T; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
  • Marzi C; Institute of Epidemiology II, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research, Partner Site Munich, Munich 85764, Germany.
  • Feitosa MF; Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108-2212, USA.
  • Lohman KK; Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
  • Kleber ME; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.
  • Milaneschi Y; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center/GGZ inGeest Research & Innovation, Amsterdam 1081 HJ, the Netherlands.
  • Mueller C; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg 20246, Germany; Institute of Medical Biometry and Statistics, University Medical Center Schleswig-Holstein, Campus Luebeck, Lübeck 23562, Germany; German Center for Cardiovascular Research, Partner Site Rhi
  • Huq M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
  • Vlachopoulou E; Transplantation Laboratory, Medicum, University of Helsinki, Helsinki 00014, Finland.
  • Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33014, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33520, Finland.
  • Oldmeadow C; Hunter Medical Research Institute, New Lambon Heights, NSW 2305, Australia; Centre for Clinical Epidemiology & Biostatistics, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia.
  • Deelen J; Molecular Epidemiology, Leiden University Medical Center, Leiden 2333 ZC, the Netherlands; Max Planck Institute for Biology of Ageing, Cologne 50931, Germany.
  • Perola M; National Institute for Health and Welfare, Helsinki 00271, Finland.
  • Zhao JH; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge CB2 0QQ, UK.
  • Feenstra B; Department of Epidemiology Research, Statens Serum Institut, Copenhagen 2300, Denmark.
  • Amini M; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
  • Lahti J; Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki 00014, Finland; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland; Folkhälsan Research Centre, Helsinki 00250, Finland.
  • Schraut KE; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH16 4UX, UK.
  • Fornage M; Human Genetics Center, School of Public Health and Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Suktitipat B; Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  • Chen WM; Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
  • Li X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
  • Nutile T; Institute of Genetics and Biophysics "A. Buzzati-Traverso," Consiglio Nazionale delle Ricerche, Napoli 80131, Italy.
  • Malerba G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona 37134, Italy.
Am J Hum Genet ; 103(5): 691-706, 2018 11 01.
Article en En | MEDLINE | ID: mdl-30388399

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Redes y Vías Metabólicas / Sitios Genéticos / Inflamación Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Redes y Vías Metabólicas / Sitios Genéticos / Inflamación Tipo de estudio: Clinical_trials / Prognostic_studies / Systematic_reviews Límite: Adolescent / Adult / Aged / Aged80 / Child / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Hum Genet Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos