Effects of RhoA and RhoC upon the sensitivity of prostate cancer cells to glutamine deprivation.
Small GTPases
; 12(1): 20-26, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-30449238
ABSTRACT
RhoA and RhoC contribute to the regulation of glutamine metabolism, which is a crucial determinant of cell growth in some types of cancer. Here we investigated the participation of RhoA and RhoC in the response of prostate cancer cells to glutamine deprivation. We found that RhoA and RhoC activities were up- or downregulated by glutamine reduction in PC3 and LNCaP cell lines, which was concomitant to a reduction in cell number and proliferation. Stable overexpression of wild type RhoA or RhoC did not alter the sensitivity to glutamine deprivation. However, PC3 cells expressing dominant negative RhoAN19 or RhoCN19 mutants were more resistant to glutamine deprivation. Our results indicate that RhoA and RhoC activities could affect cancer treatments targeting the glutamine pathway.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Glutamina
Tipo de estudio:
Diagnostic_studies
Idioma:
En
Revista:
Small GTPases
Año:
2021
Tipo del documento:
Article
País de afiliación:
Brasil