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Galectin-3 is involved in HIV-1 expression through NF-κB activation and associated with Tat in latently infected cells.
Okamoto, Mika; Hidaka, Akemi; Toyama, Masaaki; Baba, Masanori.
Afiliación
  • Okamoto M; Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, 890-8544, Japan.
  • Hidaka A; Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, 890-8544, Japan.
  • Toyama M; Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, 890-8544, Japan.
  • Baba M; Division of Antiviral Chemotherapy, Center for Chronic Viral Diseases, Kagoshima University, Kagoshima, 890-8544, Japan. Electronic address: m-baba@m2.kufm.kagoshima-u.ac.jp.
Virus Res ; 260: 86-93, 2019 01 15.
Article en En | MEDLINE | ID: mdl-30481548
Galectin-3 (Gal-3) is involved in many biological processes and pathogenesis of diseases in part through nuclear factor (NF)-κB activation. We demonstrated that Gal-3 expression was significantly induced by tumor necrosis factor (TNF)-α or phorbol 12-myristate 13-acetate in OM-10.1 and ACH-2 cells, which are considered as a model of HIV-1 latently infected cells. The expression of Gal-3 was also associated with their viral production. However, the induction of Gal-3 by TNF-α was not observed in their uninfected parental cells. Knockdown of Gal-3 resulted in the suppression of NF-κB activation and HIV-1 replication in the latently infected cells. The expression level of Gal-3 was highly correlated with that of HIV-1 Tat in the latently infected cells stimulated with TNF-α. Furthermore, colocalization and possible interaction of Gal-3 and Tat were observed in the stimulated cells. These results suggent that Gal-3 expression is closely correlated with HIV-1 expression in latently infected cells through NF-κB activation and the interaction with Tat.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Replicación Viral / FN-kappa B / VIH-1 / Galectina 3 / Productos del Gen tat del Virus de la Inmunodeficiencia Humana / Interacciones Huésped-Patógeno Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Virus Res Asunto de la revista: VIROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Replicación Viral / FN-kappa B / VIH-1 / Galectina 3 / Productos del Gen tat del Virus de la Inmunodeficiencia Humana / Interacciones Huésped-Patógeno Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Virus Res Asunto de la revista: VIROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Japón