Switching of Trp-214 intrinsic rotamer population in human serum albumin: An insight into the aftermath of embracing therapeutic bioorganic luminophore azapodophyllotoxin into sudlow site I.

Mukherjee, Soham; Ganorkar, Kapil; Kumar, Ajay; Sehra, Naina; Ghosh, Sujit Kumar

Mukherjee, Soham; Ganorkar, Kapil; Kumar, Ajay; Sehra, Naina; Ghosh, Sujit Kumar.

Afiliación

Mukherjee S; Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra 440010, India.
Ganorkar K; Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra 440010, India.
Kumar A; International Centre for Trans-disciplinary Research, School of Environmental Affairs, Universidad Metropolitana, PR 00928, United States.
Sehra N; Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra 440010, India.
Ghosh SK; Department of Chemistry, Visvesvaraya National Institute of Technology, Nagpur, Maharashtra 440010, India. Electronic address: skghosh@chm.vnit.ac.in.

Bioorg Chem ; 84: 63-75, 2019 03.

Article en En | MEDLINE | ID: mdl-30481647

Asunto(s)

Furocumarinas/química; Albúmina Sérica Humana/química; Triptófano/química; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Simulación del Acoplamiento Molecular; Estructura Molecular

Palabras clave

Azapodophyllotoxin; FRET; Fluorescence anisotropy; Human serum albumin; Molecular docking; Time-resolved fluorescence

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Furocumarinas / Triptófano / Albúmina Sérica Humana Límite: Humans Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article País de afiliación: India

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