OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGF­C expression and secretion.

Ma, Caiqi; Xie, Jinye; Luo, Chuanghua; Yin, Haofan; Li, Ruopu; Wang, Xi; Xiong, Wenjun; Zhang, Ting; Jiang, Ping; Qi, Weiwei; Zhou, Ti; Yang, Zhonghan; Wang, Wei; Ma, Jianxing; Gao, Guoquan; Yang, Xia

OxLDL promotes lymphangiogenesis and lymphatic metastasis in gastric cancer by upregulating VEGFC expression and secretion.

Ma, Caiqi; Xie, Jinye; Luo, Chuanghua; Yin, Haofan; Li, Ruopu; Wang, Xi; Xiong, Wenjun; Zhang, Ting; Jiang, Ping; Qi, Weiwei; Zhou, Ti; Yang, Zhonghan; Wang, Wei; Ma, Jianxing; Gao, Guoquan; Yang, Xia.

Afiliación

Ma C; Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Xie J; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Luo C; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Yin H; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Li R; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Wang X; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Xiong W; Department of Gastrointestinal Surgery, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, Guangdong 510080, P.R. China.
Zhang T; Department of Laboratory Medicine, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510080, P.R. China.
Jiang P; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Qi W; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Zhou T; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Yang Z; Department of Biochemistry, Zhongshan School of Medicine, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Wang W; Department of Gastrointestinal Surgery, Traditional Chinese Medicine Hospital of Guangdong Province, Guangzhou, Guangdong 510080, P.R. China.
Ma J; Department of Physiology, University of Oklahoma, Health Sciences Center, Oklahoma City, OK 73104, USA.
Gao G; Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.
Yang X; Department of Internal Medicine, Affiliated Guangzhou Women and Children's Medical Center, Sun Yatsen University, Guangzhou, Guangdong 510080, P.R. China.

Int J Oncol ; 54(2): 572-584, 2019 02.

Article en En | MEDLINE | ID: mdl-30483757

Asunto(s)

Lipoproteínas LDL/genética; Linfangiogénesis/genética; Receptores Depuradores de Clase E/genética; Neoplasias Gástricas/genética; Factor C de Crecimiento Endotelial Vascular/genética; Anciano; Animales; Línea Celular Tumoral; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Lipoproteínas LDL/sangre; Metástasis Linfática; Masculino; Ratones; Persona de Mediana Edad; FN-kappa B/genética; Factores de Riesgo; Transducción de Señal/genética; Neoplasias Gástricas/sangre; Neoplasias Gástricas/metabolismo; Neoplasias Gástricas/patología; Activación Transcripcional/genética; Factor C de Crecimiento Endotelial Vascular/sangre; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

oxidized low-density lipoprotein; lymphangiogenesis; lectin-like oxidized low-density lipoprotein receptor; nuclear factor-κB; vascular endothelia growth factor-C; lymph node metastasis; gastric cancer

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Factor C de Crecimiento Endotelial Vascular / Linfangiogénesis / Receptores Depuradores de Clase E / Lipoproteínas LDL Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article

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