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Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity.
Stella, Stefano; Mesa, Pablo; Thomsen, Johannes; Paul, Bijoya; Alcón, Pablo; Jensen, Simon B; Saligram, Bhargav; Moses, Matias E; Hatzakis, Nikos S; Montoya, Guillermo.
Afiliación
  • Stella S; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
  • Mesa P; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
  • Thomsen J; Department of Chemistry & Nanoscience Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.
  • Paul B; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
  • Alcón P; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
  • Jensen SB; Department of Chemistry & Nanoscience Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.
  • Saligram B; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
  • Moses ME; Department of Chemistry & Nanoscience Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark.
  • Hatzakis NS; Department of Chemistry & Nanoscience Centre, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark. Electronic address: hatzakis@chem.ku.dk.
  • Montoya G; Structural Molecular Biology Group, Novo Nordisk Foundation Centre for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark. Electronic address: guillermo.montoya@cpr.ku.dk.
Cell ; 175(7): 1856-1871.e21, 2018 12 13.
Article en En | MEDLINE | ID: mdl-30503205
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / ADN de Cadena Simple / ARN Guía de Kinetoplastida / División del ADN / Sistemas CRISPR-Cas / Francisella Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article País de afiliación: Dinamarca
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Bacterianas / ADN de Cadena Simple / ARN Guía de Kinetoplastida / División del ADN / Sistemas CRISPR-Cas / Francisella Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Año: 2018 Tipo del documento: Article País de afiliación: Dinamarca