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The discovery and optimization of benzimidazoles as selective NaV1.8 blockers for the treatment of pain.
Brown, Alan D; Bagal, Sharan K; Blackwell, Paul; Blakemore, David C; Brown, Bruce; Bungay, Peter J; Corless, Martin; Crawforth, James; Fengas, David; Fenwick, David R; Gray, Victoria; Kemp, Mark; Klute, Wolfgang; Malet Sanz, Laia; Miller, Duncan; Murata, Yoshihisa; Payne, C Elizabeth; Skerratt, Sarah; Stevens, Edward B; Warmus, Joseph S.
Afiliación
  • Brown AD; Pfizer Medicine Design, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Bagal SK; Pfizer Medicine Design, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Blackwell P; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Blakemore DC; Pfizer Medicine Design, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA.
  • Brown B; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Bungay PJ; Medicinal Sciences, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Corless M; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Crawforth J; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Fengas D; Concept Life Sciences, Discovery Park, Ramsgate Road, Sandwich, Kent CT13 9FF, UK.
  • Fenwick DR; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Gray V; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Kemp M; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Klute W; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Malet Sanz L; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Miller D; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Murata Y; Pfizer Medicinal Sciences, Pfizer Global R&D, Sandwich CT13 9FF, UK.
  • Payne CE; Medicinal Sciences, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Skerratt S; Pfizer Medicine Design, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Stevens EB; Medicinal Sciences, Pfizer Ltd., The Portway Building, Granta Park, Cambridge CB21 6GS, UK.
  • Warmus JS; Pfizer Medicine Design, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. Electronic address: Joseph.Warmus@pfizer.com.
Bioorg Med Chem ; 27(1): 230-239, 2019 01 01.
Article en En | MEDLINE | ID: mdl-30538065
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bencimidazoles / Canal de Sodio Activado por Voltaje NAV1.8 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bencimidazoles / Canal de Sodio Activado por Voltaje NAV1.8 / Bloqueadores del Canal de Sodio Activado por Voltaje Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido