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The identification of patient-specific mutations reveals dual pathway activation in most patients with melanoma and activated receptor tyrosine kinases in BRAF/NRAS wild-type melanomas.
Appenzeller, Silke; Gesierich, Anja; Thiem, Alexander; Hufnagel, Anita; Jessen, Christina; Kneitz, Hermann; Regensburger, Martina; Schmidt, Cornelia; Zirkenbach, Vanessa; Bischler, Thorsten; Schilling, Bastian; Siedel, Claudia; Goebeler, Maria-Elisabeth; Houben, Roland; Schrama, David; Gehrig, Andrea; Rost, Simone; Maurus, Katja; Bargou, Ralf; Rosenwald, Andreas; Schartl, Manfred; Goebeler, Matthias; Meierjohann, Svenja.
Afiliación
  • Appenzeller S; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
  • Gesierich A; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Thiem A; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
  • Hufnagel A; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Jessen C; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany.
  • Kneitz H; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany.
  • Regensburger M; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Schmidt C; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
  • Zirkenbach V; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany.
  • Bischler T; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany.
  • Schilling B; Department of Physiological Chemistry, University of Würzburg, Würzburg, Germany.
  • Siedel C; Core Unit Systems Medicine, University of Würzburg, Würzburg, Germany.
  • Goebeler ME; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Houben R; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Schrama D; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
  • Gehrig A; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Rost S; Department of Dermatology, Venereology, and Allergology and Skin Cancer Center, University Hospital Würzburg, Würzburg, Germany.
  • Maurus K; Institute of Human Genetics, University of Würzburg, Würzburg, Germany.
  • Bargou R; Institute of Human Genetics, University of Würzburg, Würzburg, Germany.
  • Rosenwald A; Institute of Pathology, University of Würzburg, Würzburg, Germany.
  • Schartl M; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
  • Goebeler M; Institute of Pathology, University of Würzburg, Würzburg, Germany.
  • Meierjohann S; Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.
Cancer ; 125(4): 586-600, 2019 02 15.
Article en En | MEDLINE | ID: mdl-30561760
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas B-raf / GTP Fosfohidrolasas / Melanoma / Proteínas de la Membrana / Mutación Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Año: 2019 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Proteínas Proto-Oncogénicas B-raf / GTP Fosfohidrolasas / Melanoma / Proteínas de la Membrana / Mutación Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Año: 2019 Tipo del documento: Article País de afiliación: Alemania