Origin, Organization, Dynamics, and Function of Actin and Actomyosin Networks at the T Cell Immunological Synapse.
Annu Rev Immunol
; 37: 201-224, 2019 04 26.
Article
en En
| MEDLINE
| ID: mdl-30576253
ABSTRACT
The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks. These networks reside largely within a narrow zone immediately under the T cell's plasma membrane at its site of contact with the APC or activating surface, i.e., at the immunological synapse. Here we review the origin, organization, dynamics, and function of these synapse-associated actin and actomyosin networks. Importantly, recent insights into the nature of these actin-based cytoskeletal structures were made possible in several cases by advances in light microscopy.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Citoesqueleto
/
Actomiosina
/
Linfocitos T
/
Actinas
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Sinapsis Inmunológicas
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Células Presentadoras de Antígenos
Límite:
Animals
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Humans
Idioma:
En
Revista:
Annu Rev Immunol
Año:
2019
Tipo del documento:
Article