Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms.

Song, Dae-Geun; Kim, Doyeun; Jung, Jae Woo; Nam, Seo Hee; Kim, Ji Eon; Kim, Hye-Jin; Kim, Jong Hyun; Lee, Seo-Jin; Pan, Cheol-Ho; Kim, Sunghoon; Lee, Jung Weon

Song, Dae-Geun; Kim, Doyeun; Jung, Jae Woo; Nam, Seo Hee; Kim, Ji Eon; Kim, Hye-Jin; Kim, Jong Hyun; Lee, Seo-Jin; Pan, Cheol-Ho; Kim, Sunghoon; Lee, Jung Weon.

Afiliación

Song DG; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim D; Systems Biotechnology Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si, Republic of Korea.
Jung JW; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.
Nam SH; Interdisciplinary Program in Genetic Engineering, Seoul National University, Seoul, Republic of Korea; and.
Kim JE; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim HJ; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Kim JH; Department of Pharmacy, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, South Korea.
Lee SJ; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.
Pan CH; Department of Life Science and Biotechnology, Shingyeong University, Gyeonggi-do, Republic of Korea.
Kim S; Systems Biotechnology Research Center, Korea Institute of Science and Technology (KIST), Gangneung-si, Republic of Korea.
Lee JW; Medicinal Bioconvergence Research Center, Seoul National University, Seoul, South Korea.

FASEB J ; 33(3): 4341-4354, 2019 03.

Article en En | MEDLINE | ID: mdl-30592630

Asunto(s)

Aminoacil-ARNt Sintetasas/metabolismo; Matriz Extracelular/metabolismo; Biosíntesis de Proteínas/genética; Transcripción Genética/genética; Aminoacil-ARNt Sintetasas/genética; Animales; Línea Celular; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Regulación hacia Abajo/genética; Matriz Extracelular/genética; Fibrosis/genética; Fibrosis/metabolismo; Células Estrelladas Hepáticas/metabolismo; Humanos; Hígado/metabolismo; Cirrosis Hepática/genética; Cirrosis Hepática/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Transducción de Señal/genética; Factor de Crecimiento Transformador beta1/genética; Factor de Crecimiento Transformador beta1/metabolismo; Regulación hacia Arriba/genética

Palabras clave

STAT6; fibrotic animal model; hepatic stellate cells; prolyl-tRNA-synthetase; signal transduction

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transcripción Genética / Biosíntesis de Proteínas / Matriz Extracelular / Aminoacil-ARNt Sintetasas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Corea del Sur

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google