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Splenic irradiation before allogeneic stem cell transplantation for myelofibrosis.
Helbig, Grzegorz; Wieczorkiewicz-Kabut, Agata; Markiewicz, Miroslaw; Krzemien, Helena; Wójciak, Michal; Bialas, Krzysztof; Kopera, Malgorzata; Rzenno, Ewa; Wozniczka, Krzysztof; Kopinska, Anna; Grygoruk-Wisniowska, Iwona; Koclega, Anna.
Afiliación
  • Helbig G; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland. ghelbig@o2.pl.
  • Wieczorkiewicz-Kabut A; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Markiewicz M; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Krzemien H; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Wójciak M; Students' Research Group, Medical University of Warsaw, Warsaw, Poland.
  • Bialas K; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Kopera M; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Rzenno E; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Wozniczka K; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Kopinska A; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Grygoruk-Wisniowska I; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
  • Koclega A; Department of Hematology and Bone Marrow Transplantation, School of Medicine in Katowice, Medical University of Silesia, Dabrowski Street 25, 40-032, Katowice, Poland.
Med Oncol ; 36(2): 16, 2019 Jan 08.
Article en En | MEDLINE | ID: mdl-30617767
ABSTRACT
Splenectomy before allogeneic stem cell transplantation (ASCT) for patients with myelofibrosis (MF) remains a matter of debate, and conflicting results have been reported to date. The procedure seems to fasten post-transplant hematological recovery, but it does not have an impact on survival. The role of pre-transplant splenic irradiation (SI) is much more difficult to evaluate. Forty-four patients (25 males and 19 females) with MF at median age of 49 years at diagnosis (range 14-67) underwent ASCT. The post-transplant outcome was compared between irradiated and non-irradiated patients. Eleven patients received irradiation before transplantation. Median dose of radiation was 1000 cGy (range 600-2400). There was no difference in median time to engraftment between patients with and without previous radiotherapy. Acute and chronic graft versus host disease (GVHD) occurred in 47% and 36% of patients, respectively. There was no difference in GVHD incidence between groups. Eight patients relapsed/progressed in irradiated group versus 17 in non-irradiated (70% vs. 51%; p = 0.3). Transformation to acute myeloid leukemia was observed in 3 patients 2 in irradiated and 1 in non-irradiated group. In total, 22 patients died with no statistical difference in death rate between irradiated and non-irradiated subjects. The probability of overall survival after transplant for the entire cohort at 2 years was 54% (72% for irradiated and 48% for non-irradiated patients; p = 0.25). Splenic irradiation prior to ASCT for myelofibrosis has not beneficial effect on post-transplant outcome.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bazo / Trasplante de Células Madre / Mielofibrosis Primaria Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Polonia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Bazo / Trasplante de Células Madre / Mielofibrosis Primaria Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Med Oncol Asunto de la revista: NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: Polonia