Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy.

Zhou, Li; Gao, Wei; Wang, Kui; Huang, Zhao; Zhang, Lu; Zhang, Zhe; Zhou, Jing; Nice, Edouard C; Huang, Canhua

Zhou, Li; Gao, Wei; Wang, Kui; Huang, Zhao; Zhang, Lu; Zhang, Zhe; Zhou, Jing; Nice, Edouard C; Huang, Canhua.

Afiliación

Zhou L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Gao W; West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, China.
Wang K; Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Huang Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Zhang L; West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, China.
Zhang Z; Department of Oncology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Zhou J; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Nice EC; West China School of Basic Sciences and Forensic Medicine, Sichuan University, Chengdu, China.
Huang C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

FASEB J ; 33(4): 5520-5534, 2019 04.

Article en En | MEDLINE | ID: mdl-30668917

Asunto(s)

Autofagia/efectos de los fármacos; Brefeldino A/farmacología; Proliferación Celular/efectos de los fármacos; Neoplasias Colorrectales/tratamiento farmacológico; Proteínas Proto-Oncogénicas c-akt/metabolismo; Animales; Antineoplásicos/farmacología; Línea Celular Tumoral; Neoplasias Colorrectales/metabolismo; Estrés del Retículo Endoplásmico/efectos de los fármacos; Células HCT116; Células HT29; Humanos; Linfocinas/metabolismo; Macrólidos/metabolismo; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos

Palabras clave

ER stress; autophagic flux; cancer therapy

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Autofagia / Neoplasias Colorrectales / Brefeldino A / Proliferación Celular / Proteínas Proto-Oncogénicas c-akt Límite: Animals / Humans Idioma: En Revista: FASEB J Asunto de la revista: BIOLOGIA / FISIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China

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