Development of the central nervous system in equine twin fetuses derived by somatic cell nuclear transfer.
Reprod Fertil Dev
; 31(5): 941-952, 2019 Apr.
Article
en En
| MEDLINE
| ID: mdl-30689958
ABSTRACT
Because of the growing importance of horses in leisure and several sports, somatic cell nuclear transfer (SCNT) is being used more frequently for cloning animals for performance and reproductive purposes. However, because of the need to perforate the zona pellucida during microsurgical reconstruction of the oocyte, it is possible that SCNT-derived embryos undergo premature hatching, resulting in embryo bisection and twinning. Therefore, because equine twin pregnancies often lead to abnormal embryo development and pregnancy failure, we performed a detailed comparative assessment of equine twin fetuses derived by SCNT with particular attention on the development of the central nervous system at 40 and 60 days gestation. The results of this study indicate that although cloned twin embryos show small differences in size, they do not exhibit apparent macro- or microscopic developmental discrepancies in the central nervous system, suggesting that the twining phenomenon resulting from SCNT does not affect fetal differentiation.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Central
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Desarrollo Embrionario
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Desarrollo Fetal
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Embrión de Mamíferos
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Técnicas de Transferencia Nuclear
Límite:
Animals
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Pregnancy
Idioma:
En
Revista:
Reprod Fertil Dev
Asunto de la revista:
MEDICINA REPRODUTIVA
Año:
2019
Tipo del documento:
Article