Relapse-associated AURKB blunts the glucocorticoid sensitivity of B cell acute lymphoblastic leukemia.

Poulard, Coralie; Kim, Hye Na; Fang, Mimi; Kruth, Karina; Gagnieux, Celine; Gerke, Daniel S; Bhojwani, Deepa; Kim, Yong-Mi; Kampmann, Martin; Stallcup, Michael R; Pufall, Miles A

Poulard, Coralie; Kim, Hye Na; Fang, Mimi; Kruth, Karina; Gagnieux, Celine; Gerke, Daniel S; Bhojwani, Deepa; Kim, Yong-Mi; Kampmann, Martin; Stallcup, Michael R; Pufall, Miles A.

Afiliación

Poulard C; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089.
Kim HN; Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Fang M; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Kruth K; Department of Biochemistry, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Gagnieux C; Department of Biochemistry, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52242.
Gerke DS; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089.
Bhojwani D; Department of Biochemistry and Molecular Medicine, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089.
Kim YM; Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Kampmann M; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.
Stallcup MR; Department of Pediatrics, Division of Hematology, Oncology, and Bone Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027.
Pufall MA; Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033.

Proc Natl Acad Sci U S A ; 116(8): 3052-3061, 2019 02 19.

Article en En | MEDLINE | ID: mdl-30733284

Asunto(s)

Aurora Quinasa B/genética; Muerte Celular/genética; Resistencia a Antineoplásicos/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras B/tratamiento farmacológico; Línea Celular Tumoral; Proteínas Cromosómicas no Histona/genética; Regulación Leucémica de la Expresión Génica/genética; Glucocorticoides/genética; Glucocorticoides/farmacología; Antígenos de Histocompatibilidad/genética; N-Metiltransferasa de Histona-Lisina/genética; Humanos; Leucemia-Linfoma Linfoblástico de Células Precursoras B/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras B/patología; ARN Interferente Pequeño/genética; Recurrencia

Palabras clave

AURKB; cell death; coregulator; glucocorticoid; leukemia

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras B / Muerte Celular / Resistencia a Antineoplásicos / Aurora Quinasa B Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article

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