Dose Optimization of Colistin Combinations against Carbapenem-Resistant Acinetobacter baumannii from Patients with Hospital-Acquired Pneumonia in China by Using an <i>In Vitro</i> Pharmacokinetic/Pharmacodynamic Model.

Bian, Xingchen; Liu, Xiaofen; Chen, Yuancheng; Chen, Daijie; Li, Jian; Zhang, Jing

Dose Optimization of Colistin Combinations against Carbapenem-Resistant Acinetobacter baumannii from Patients with Hospital-Acquired Pneumonia in China by Using an In Vitro Pharmacokinetic/Pharmacodynamic Model.

Bian, Xingchen; Liu, Xiaofen; Chen, Yuancheng; Chen, Daijie; Li, Jian; Zhang, Jing.

Afiliación

Bian X; Institute of Antibiotics, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Liu X; College of Life Sciences, Shanghai Normal University, Shanghai, China.
Chen Y; Institute of Antibiotics, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Chen D; Institute of Antibiotics, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China.
Li J; Phase I Unit, Huashan Hospital, Fudan University, Shanghai, China.
Zhang J; Shanghai Jiaotong University, Shanghai, China.

Antimicrob Agents Chemother ; 63(4)2019 04.

Article en En | MEDLINE | ID: mdl-30745385

Asunto(s)

Infecciones por Acinetobacter/microbiología; Acinetobacter baumannii/efectos de los fármacos; Antibacterianos/administración & dosificación; Colistina/administración & dosificación; Neumonía Asociada a la Atención Médica/microbiología; Antibacterianos/farmacocinética; Antibacterianos/farmacología; Carbapenémicos/farmacología; China; Colistina/farmacocinética; Colistina/farmacología; Sinergismo Farmacológico; Quimioterapia Combinada; Humanos; Meropenem/farmacología; Pruebas de Sensibilidad Microbiana; Modelos Biológicos; Neumonía Bacteriana/microbiología; Reproducibilidad de los Resultados; Resistencia betalactámica

Palabras clave

Acinetobacter baumannii; PK/PD modeling; carbapenem resistance; colistin; combination therapy; meropenem

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infecciones por Acinetobacter / Colistina / Acinetobacter baumannii / Neumonía Asociada a la Atención Médica / Antibacterianos Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2019 Tipo del documento: Article País de afiliación: China

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