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Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure.
Milite, Ciro; Feoli, Alessandra; Horton, John R; Rescigno, Donatella; Cipriano, Alessandra; Pisapia, Vincenzo; Viviano, Monica; Pepe, Giacomo; Amendola, Giorgio; Novellino, Ettore; Cosconati, Sandro; Cheng, Xiaodong; Castellano, Sabrina; Sbardella, Gianluca.
Afiliación
  • Horton JR; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
  • Amendola G; DiSTABiF , University of Campania "Luigi Vanvitelli" , Via Vivaldi 43 , 81100 Caserta , Italy.
  • Novellino E; Department of Pharmacy , University Federico II of Naples , Via D. Montesano 49 , 80131 Naples , Italy.
  • Cosconati S; DiSTABiF , University of Campania "Luigi Vanvitelli" , Via Vivaldi 43 , 81100 Caserta , Italy.
  • Cheng X; Department of Molecular and Cellular Oncology , The University of Texas MD Anderson Cancer Center , Houston , Texas 77030 , United States.
J Med Chem ; 62(5): 2666-2689, 2019 03 14.
Article en En | MEDLINE | ID: mdl-30753076
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Diseño de Fármacos / N-Metiltransferasa de Histona-Lisina / Inhibidores Enzimáticos / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Diseño de Fármacos / N-Metiltransferasa de Histona-Lisina / Inhibidores Enzimáticos / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2019 Tipo del documento: Article