Impact of Menthol on Oral Nicotine Consumption in Female and Male Sprague Dawley Rats.
Nicotine Tob Res
; 22(2): 196-203, 2020 02 06.
Article
en En
| MEDLINE
| ID: mdl-30753589
ABSTRACT
INTRODUCTION:
One of the preferable flavors in oral nicotine delivery systems is menthol which masks the harshness of tobacco. However, possible interactions between oral menthol and nicotine on intake and preference remain unclear. Therefore, we aimed to determine the impact of menthol on oral nicotine consumption.METHODS:
Adult Sprague Dawley female and male rats (n = 8 per group) were given a choice of water or drug solution by using two-bottle free choice paradigm for 2 weeks vehicle (5% ethanol), nicotine (20 mg/L), menthol (1 g/L) and mentholated nicotine groups. At the end of the study, plasma nicotine levels were determined.RESULTS:
When rats were given a choice of nicotine or water, nicotine intake was similar between female and male rats. Menthol addition to nicotine solution significantly increased nicotine intake and preference in male but not female rats without a considerable effect on total fluid intake and body weight change in either sex. The average nicotine intake in male rats was 0.5 ± 0.05 and 1.4 ± 0.12 mg/kg/day for nicotine and menthol-nicotine combination (p < .05), respectively. The average nicotine intake in female rats was 0.6 ± 0.05 and 0.6 ± 0.03 mg/kg/day for nicotine and menthol-nicotine combination (p > .05), respectively. Plasma nicotine levels were not significantly different between the groups in either male (nicotine group 20.8 ± 4.9, mentholated nicotine group 31.9 ± 3.2 ng/mL) or female (nicotine group 24.0 ± 3.3, mentholated nicotine group 17.8 ± 2.9 ng/mL) rats (p > .05).CONCLUSIONS:
Menthol increases oral nicotine consumption in male, but not female, rats. IMPLICATIONS This study may provide data on the co-use of menthol and nicotine in smokeless tobacco, particularly oral dissolvable tobacco products.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Gusto
/
Caracteres Sexuales
/
Aromatizantes
/
Mentol
/
Nicotina
Límite:
Animals
Idioma:
En
Revista:
Nicotine Tob Res
Asunto de la revista:
SAUDE PUBLICA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Ciudad del Vaticano