Marked Vascular Dysfunction in a Case of Peripartum Cardiomyopathy.
J Vasc Res
; 56(1): 11-15, 2019.
Article
en En
| MEDLINE
| ID: mdl-30763932
ABSTRACT
Peripartum cardiomyopathy (PPCM) is a rare form of congestive heart failure characterized by left ventricular dysfunction that develops towards the end of pregnancy or during the early postpartum phase. Even though the majority of PPCM patients show partial or complete recovery of their heart functions, the mortality rate of PPCM remains high. Previous research has suggested that vascular dysfunction triggered by late-gestational hormones and potent anti-angiogenic factors play key roles in the pathogenesis of PPCM; however, the exact mechanisms remain elusive due to limited patient tissues for characterization. Here, we report a case of PPCM where the coronary vessels from the patient's explanted heart showed marked vascular dysfunction with impaired nitric oxide response. Importantly, these vessels exhibited deficient adenosine-mediated vasorelaxation when subjected to myograph studies, suggesting impaired Kv7 ion channels. Results from this work may lead to new therapeutic strategies for improving Kv7 function in PPCM patients.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Vasodilatación
/
Enfermedad de la Arteria Coronaria
/
Función Ventricular Izquierda
/
Disfunción Ventricular Izquierda
/
Vasos Coronarios
/
Periodo Periparto
/
Cardiomiopatías
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Middle aged
/
Pregnancy
Idioma:
En
Revista:
J Vasc Res
Asunto de la revista:
ANGIOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos