Gcn5 histone acetyltransferase is present in the mitoplasts.
Biol Open
; 8(2)2019 Feb 18.
Article
en En
| MEDLINE
| ID: mdl-30777878
ABSTRACT
In Saccharomyces cerevisiae the Lysine-acetyltransferase Gcn5 (KAT2) is part of the SAGA complex and is responsible for histone acetylation widely or at specific lysines. In this paper we report that G CN5 deletion differently affects the growth of two strains. The defective mitochondrial phenotype is related to a marked decrease in mtDNA content, which also involves the deletion of specific regions of the molecule. We also show that in wild-type mitochondria the Gcn5 protein is present in the mitoplasts, suggesting a new mitochondrial function independent from the SAGA complex and possibly a new function for this protein connecting epigenetics and metabolism.
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Bases de datos:
MEDLINE
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En
Revista:
Biol Open
Año:
2019
Tipo del documento:
Article
País de afiliación:
Italia